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Naltrexone
Pharmacological extinction uses naltrexone, an opioid antagonist, to block positive reinforcement from alcohol. Naltrexone is a well known medicine used clinically for over 10 years. It is not addictive itself, nor does it cause a dangerous disulfiram-like reaction after drinking alcohol.
How naltrexone works
Naltrexone blocks the effects of morphine and also endogenous opiates (and thus the reinforcement from alcohol) by fitting into opiate receptors well enough to keep opiates themselves out, but not well enough to produce any narcotic effects of its own. - Like the wrong key in a lock.
The effectiveness of naltrexone and other opiate antagonists has been shown in laboratory studies and clinical trials
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